Product Description
USP2 Antibody (Ctr S260) [APR04806G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This USP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-275 amino acids from human USP2.
Cellular Localisation: Cytoplasm {ECO:0000250|UniProtKB:O88623}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O88623} Note=Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane. {ECO:0000250|UniProtKB:Q5U349}
Molecular Weight: 68072
Clone: Polyclonal
Gene Name: USP2
Gene ID: 9099
Function: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1 (PubMed:17290220, PubMed:19917254, PubMed:19838211) . Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities (By similarity) . Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity (PubMed:17290220, PubMed:19838211) . Has no deubiquitinase activity against p53/TP53 (PubMed:17290220) . Prevents MDM2-mediated degradation of MDM4 (PubMed:17290220) . Plays a role in the G1/S cell-cycle progression in normal and cancer cells (PubMed:19917254) . Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues (By similarity) . Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability (By similarity) . Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity) . Plays a role in the regulation of myogenic differentiation of embryonic muscle cells (By similarity) .
Summary: Tissue Location: Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level)
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: N/A
Dilution: N/A
Synonyms: Ubiquitin carboxyl-terminal hydrolase 2, 41 kDa ubiquitin-specific protease, Deubiquitinating enzyme 2, Ubiquitin thioesterase 2, Ubiquitin-specific-processing protease 2, USP2, UBP41