Product Description
ANGPTL7 Antibody (C-term) [APR14087G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This ANGPTL7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 315-346 amino acids from the C-terminal region of human ANGPTL7.
Cellular Localisation: Secreted.
Molecular Weight: 40018
Clone: Polyclonal
Gene Name: ANGPTL7
Gene ID: 10218
Function: Has a role in the formation and organization of the extracellular matrix. In the eye, it functions as a mediator of dexamethasone-induced matrix deposition in the trabecular meshwork, the tissue responsible for the outflow of the ocular aqueous humor and for the maintenance of intraocular pressure (PubMed:21199193) . Is a negative regulator of angiogenesis in the cornea, and plays a major role in maintaining corneal avascularity and transparency (PubMed:25622036) .
Summary: Tissue Location: Higly expressed in the cornea (at protein level) (PubMed:11682471) . Expression is restricted to the stromal layer (PubMed:11682471) . Also detected at the junction between the corneal stromal layer and the conjuctiva. Not detected in the sclera (PubMed:11682471) .
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P, FC
Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50
Synonyms: Angiopoietin-related protein 7, Angiopoietin-like factor, Angiopoietin-like protein 7, Cornea-derived transcript 6 protein, ANGPTL7, CDT6