Product Description
AQP5 Antibody (C-term) [APG01967G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This AQP5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-256 amino acids from the C-terminal region of human AQP5.
Cellular Localisation: Apical cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein Note=Hypotonicity increases location at the cell membrane Phosphorylation decreases location at the cell membrane
Molecular Weight: 28292
Clone: Polyclonal
Gene Name: AQP5
Gene ID: 362
Function: Forms a water-specific channel (PubMed:8621489, PubMed:18768791) . Plays an important role in fluid secretion in salivary glands (By similarity) . Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells (PubMed:16571723) . Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity) .
Summary: Tissue Location: Detected in skin eccrine sweat glands, at the apical cell membrane and at intercellular canaliculi (at protein level) .
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, FC
Dilution: FC--1:25 WB--1:2000
Synonyms: Aquaporin-5, AQP-5, AQP5