Product Description
COQ6 Antibody (N-term) [APG02701G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This COQ6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-83 amino acids from the N-terminal region of human COQ6.
Cellular Localisation: Mitochondrion inner membrane {ECO:0000255|HAMAP- Rule:MF_03193}; Peripheral membrane protein {ECO:0000255|HAMAP- Rule:MF_03193}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03193}. Golgi apparatus {ECO:0000255|HAMAP-Rule:MF_03193}. Cell projection {ECO:0000255|HAMAP-Rule:MF_03193}. Note=Localizes to cell processes and Golgi apparatus in podocytes. {ECO:0000255|HAMAP-Rule:MF_03193}
Molecular Weight: 50870
Clone: Polyclonal
Gene Name: COQ6 {ECO:0000255|HAMAP-Rule:MF_03193}
Gene ID: 51004
Function: FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-hexaprenyl-4-hydroxybenzoic acid (HHB) to 3- hexaprenyl-4, 5-dihydroxybenzoic acid (DHHB) . The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6 (By similarity) . Is able to perform the deamination reaction at C4 of 3-hexaprenyl-4-amino-5- hydroxybenzoic acid (HHAB) to produce DHHB when expressed in yeast cells lacking COQ9, even if utilization of para-aminobenzoic acid (pABA) involving C4-deamination seems not to occur in bacteria, plants and mammals, where only C5 hydroxylation of HHB has been shown (PubMed:26260787) .
Summary: Tissue Location: Widely expressed..
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Ubiquinone biosynthesis monooxygenase COQ6, 11413-, Coenzyme Q10 monooxygenase 6, COQ6