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Product Description
HPR Antibody (Center) [APR03529G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This HPR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 212-240 amino acids from the Central region of human HPR.
Cellular Localisation: Secreted. Note=Secreted into blood plasma and associated with subtypes of high density lipoproteins (HDL) .
Molecular Weight: 39030
Clone: Polyclonal
Gene Name: HPR
Gene ID: 3250
Function: Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I) -containing high-density lipoprotein (HDL) . This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron.
Summary: Tissue Location: In adult liver the amount of HPR mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000-fold that of the HP1F gene. No HPR mRNA can be detected in fetal liver. Expressed in Hep-G2 and leukemia MOLT-4 cell lines.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: IHC-P, WB
Dilution: WB--1:16000
Synonyms: Haptoglobin-related protein, HPR
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