Product Description
MARCKSL1 Antibody (C-term) [APR17312G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This MARCKSL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-160 amino acids from the C-terminal region of human MARCKSL1.
Cellular Localisation: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P28667}. Cell membrane; Lipid- anchor. Note=Associates with the membrane via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain. Association of the effector domain with membranes may be regulated by Ca (2+) /calmodulin. Colocalizes with F-actin at the leading edge of migrating cells (By similarity) . In prostate cancers, shows strong expression at apical and/or basal regions of the cell and also has weak cytoplasmic expression (PubMed:22751924) . {ECO:0000250|UniProtKB:P28667, ECO:0000269|PubMed:22751924}
Molecular Weight: 19529
Clone: Polyclonal
Gene Name: MARCKSL1
Gene ID: 65108
Function: Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation (PubMed:22751924) . When unphosphorylated, induces cell migration (By similarity) . When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration (By similarity) . May be involved in coupling the protein kinase C and calmodulin signal transduction systems (By similarity) .
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: MARCKS-related protein, MARCKS-like protein 1, Macrophage myristoylated alanine-rich C kinase substrate, Mac-MARCKS, MacMARCKS, MARCKSL1, MLP, MRP