Product Description
MUC20 Antibody (N-term) [APR14295G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This MUC20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-90 amino acids from the N-terminal region of human MUC20.
Cellular Localisation: Secreted. Apical cell membrane. Basolateral cell membrane. Cell projection, microvillus membrane
Molecular Weight: 71982
Clone: Polyclonal
Gene Name: MUC20
Gene ID: 200958
Function: May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF) -induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.
Summary: Tissue Location: Highly expressed in kidney, moderately in placenta, lung, prostate, liver, and digestive system. In the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules Detected in most of the male urogenital tract epithelia, with the exception of epididymis.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IF
Dilution: WB--1:2000
Synonyms: Mucin-20, MUC-20, MUC20, KIAA1359