Product Description
GABARAPL2Antibody [APR07106G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: M
Specificity: This GABARAPL2 antibody is generated from rabbits immunized with human GABARAPL2 recombinant protein.
Cellular Localisation: Cytoplasmic vesicle, autophagosome. Endoplasmic reticulum membrane. Golgi apparatus {ECO:0000250|UniProtKB:P60519}
Molecular Weight: 13667
Clone: Polyclonal
Gene Name: GABARAPL2
Gene ID: 11345
Function: Ubiquitin-like modifier involved in intra-Golgi traffic (By similarity) . Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation (By similarity) . It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity) . Involved in autophagy (PubMed:20418806, PubMed:23209295) . Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:20418806, PubMed:23209295) . Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20418806, PubMed:23209295) .
Summary: Tissue Location: Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: IHC-P, FC, WB
Dilution: WB--1:500
Synonyms: Gamma-aminobutyric acid receptor-associated protein-like 2, GABA (A) receptor-associated protein-like 2, Ganglioside expression factor 2, GEF-2, General protein transport factor p16, Golgi-associated ATPase enhancer of 16 kDa, GATE-16, MAP1 light chain 3-related protein, GABARAPL2, FLC3A, GEF2