Product Description
OTOP1 Antibody (Center) [APR30882G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: M
Specificity: This OTOP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 360-388 amino acids from the Central region of human OTOP1.
Cellular Localisation: Cell membrane {ECO:0000250|UniProtKB:Q80VM9}; Multi-pass membrane protein. Note=Detected in the gelatinous membrane overlying the inner ear macular epithelium {ECO:0000250|UniProtKB:Q80VM9}
Molecular Weight: 67353
Clone: Polyclonal
Gene Name: OTOP1 {ECO:0000303|PubMed:12651873, ECO:0000312|HGNC:HGNC:19656}
Gene ID: 133060
Function: Proton-selective channel that specifically transports protons into cells (PubMed:29371428) . Proton channel activity is only weakly- sensitive to voltage (By similarity) . Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes (PubMed:29371428) . In the vestibular system of the inner ear, required for the formation and function of otoconia, which are calcium carbonate crystals that sense gravity and acceleration (By similarity) . Probably acts by maintaining the pH appropriate for formation of otoconia (By similarity) . Regulates purinergic control of intracellular calcium in vestibular supporting cells (By similarity) . May be involved in sour taste perception in sour taste cells by mediating entry of protons within the cytosol (By similarity) . Also involved in energy metabolism, by reducing adipose tissue inflammation and protecting from obesity-induced metabolic dysfunction (By similarity) .
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P
Dilution: WB--1:2000
Synonyms: Otopetrin-1, OTOP1