Product Description
UNC5B Antibody (Center) [APR13926G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: M, Rat
Specificity: This UNC5B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 507-541 amino acids from the Central region of human UNC5B.
Cellular Localisation: Cell membrane; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O08722} Membrane raft {ECO:0000250|UniProtKB:O08722}. Note=Associated with lipid rafts. {ECO:0000250|UniProtKB:O08722}
Molecular Weight: 103638
Clone: Polyclonal
Gene Name: UNC5B
Gene ID: 219699
Function: Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion (By similarity) . Functions as netrin receptor that negatively regulates vascular branching during angiogenesis. Mediates retraction of tip cell filopodia on endothelial growth cones in response to netrin (By similarity) . It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:12598906) . Mediates apoptosis by activating DAPK1. In the absence of NTN1, activates DAPK1 by reducing its autoinhibitory phosphorylation at Ser-308 thereby increasing its catalytic activity (By similarity) .
Summary: Tissue Location: Highly expressed in brain. Also expressed at lower level in developing lung, cartilage, kidney and hematopoietic and immune tissues.
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:2000
Synonyms: Netrin receptor UNC5B, Protein unc-5 homolog 2, Protein unc-5 homolog B, p53-regulated receptor for death and life protein 1, UNC5B, P53RDL1, UNC5H2