Product Description
WASL Antibody (N-term) [AMM08505G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: M, Rat
Specificity: This WASL antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 165-198 amino acids from the N-terminal region of human WASL.
Cellular Localisation: Cytoplasm, cytoskeleton. Nucleus Cytoplasm {ECO:0000250|UniProtKB:Q91YD9}. Note=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated (By similarity) . Exported from the nucleus by an nuclear export signal (NES) -dependent mechanism to the cytoplasm (By similarity) . {ECO:0000250|UniProtKB:Q91YD9}
Molecular Weight: 54827
Clone: Polyclonal
Gene Name: WASL
Gene ID: 8976
Function: Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex (PubMed:9422512, PubMed:16767080, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828) . Involved in various processes, such as mitosis and cytokinesis, via its role in the regulation of actin polymerization (PubMed:9422512, PubMed:19366662, PubMed:19487689, PubMed:22847007, PubMed:22921828) . Together with CDC42, involved in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia (PubMed:9422512) . In addition to its role in the cytoplasm, also plays a role in the nucleus by regulating gene transcription, probably by promoting nuclear actin polymerization (PubMed:16767080) . Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression (By similarity) . Plays a role in dendrite spine morphogenesis (By similarity) . Decreasing levels of DNMBP (using antisense RNA) alters apical junction morphology in cultured enterocytes, junctions curve instead of being nearly linear (PubMed:19767742) .
Summary: N/A
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:2000
Synonyms: Neural Wiskott-Aldrich syndrome protein, N-WASP, WASL