Product Description
ERG25 Antibody (C-term) [APR31180G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This ERG25 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 264-293 amino acids from the C-terminal region of human ERG25.
Cellular Localisation: Endoplasmic reticulum membrane; Multi-pass membrane protein
Molecular Weight: 35216
Clone: Polyclonal
Gene Name: MSMO1
Gene ID: 6307
Function: Catalyzes the three-step monooxygenation required for the demethylation of 4, 4-dimethyl and 4alpha-methylsterols, which can be subsequently metabolized to cholesterol (PubMed:21285510, PubMed:28673550, PubMed:23583456, PubMed:26114596) . Also involved in drug metabolism, as it can metabolize eldecalcitol (ED-71 or 1alpha, 25- dihydroxy-2beta- (3-hydroxypropoxy) -cholecalciferol), a second- generation vitamin D analog, into 1alpha, 2beta, 25-trihydroxy vitamin D3; this reaction occurs via enzymatic hydroxylation and spontaneous O- dehydroxypropylation (PubMed:26038696) .
Summary: N/A
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P
Dilution: WB--1:1000 IHC-P--1:100~500
Synonyms: Methylsterol monooxygenase 1, C-4 methylsterol oxidase, MSMO1, DESP4, ERG25, SC4MOL