Product Description
ESRP1 Antibody (N-term) [APR32217G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This ESRP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 182-211 amino acids of human ESRP1.
Cellular Localisation: Nucleus.
Molecular Weight: 75585
Clone: Polyclonal
Gene Name: ESRP1
Gene ID: 54845
Function: mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT) . Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (PubMed:19285943) . Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity) .
Summary: Tissue Location: Epithelial cell-specific.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P
Dilution: WB--1:1000
Synonyms: Epithelial splicing regulatory protein 1, RNA-binding motif protein 35A, RNA-binding protein 35A, ESRP1, RBM35A