Product Description
HIST1H2BA Antibody (N-term) [APR31685G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This HIST1H2BA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human HIST1H2BA.
Cellular Localisation: Nucleus {ECO:0000250|UniProtKB:P70696}. Chromosome {ECO:0000250|UniProtKB:P70696}
Molecular Weight: 14167
Clone: Polyclonal
Gene Name: H2BC1 (HGNC:18730)
Gene ID: 255626
Function: Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (By similarity) . Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (By similarity) . Core component of nucleosome (By similarity) . Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By similarity) . Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (By similarity) . DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity) . Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear (PubMed:21249133) .
Summary: Tissue Location: Mainly expressed in testis, and the corresponding protein is also present in mature sperm (at protein level) . Also found in some fat cells.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Histone H2B type 1-A, Histone H2B, testis, TSH2B1, Testis-specific histone H2B, HIST1H2BA, TSH2B