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Product Description
MEN1 Antibody (T594) [APR32434G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This MEN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 584-615 amino acids from human MEN1.
Cellular Localisation: Nucleus. Note=Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation
Molecular Weight: 68023
Clone: Polyclonal
Gene Name: MEN1
Gene ID: 4221
Function: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4) . Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity) . May be involved in DNA repair.
Summary: Tissue Location: Ubiquitous.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P, IF
Dilution: WB--1:1000 IHC-P--1:100~500 IF--1:10~50
Synonyms: Menin, MEN1, SCG2
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