Product Description
METTL1 Antibody (Center) [APR32746G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This METTL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-175 amino acids from the Central region of human METTL1.
Cellular Localisation: Nucleus
Molecular Weight: 31471
Clone: Polyclonal
Gene Name: METTL1 {ECO:0000255|HAMAP-Rule:MF_03055, ECO:0000312|HGNC:HGNC:7030}
Gene ID: 4234
Function: Methyltransferase that mediates the formation of N (7) - methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (PubMed:12403464, PubMed:31031084, PubMed:31031083) . Catalyzes the formation of N (7) -methylguanine at position 46 (m7G46) in tRNA (PubMed:12403464, PubMed:31031084) . Also acts as a methyltransferase for a subset of internal N (7) -methylguanine in mRNAs (PubMed:31031084) . Internal N (7) -methylguanine methylation of mRNAs regulates translation (PubMed:31031084) . Also methylates a specific subset of miRNAs, such as let-7 (PubMed:31031083) . N (7) -methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA) (PubMed:31031083) . Acts as a regulator of embryonic stem cell self-renewal and differentiation (By similarity) .
Summary: Tissue Location: Ubiquitous..
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: tRNA (guanine-N (7) -) -methyltransferase {ECO:0000255|HAMAP-Rule:MF_03055}, 21133 {ECO:0000255|HAMAP-Rule:MF_03055}, Methyltransferase-like protein 1 {ECO:0000255|HAMAP-Rule:MF_03055}, tRNA (guanine (46) -N (7) ) -methyltransferase {ECO:0000255|HAMAP-Rule:MF_03055}, tRNA (m7G46) -methyltransferase {ECO:0000255|HAMAP-Rule:MF_03055}, METTL1 {ECO:0000255|HAMAP-Rule:MF_03055}, C12orf1