Product Description
NUR77 (NR4A1) Antibody (S351) [APR32269G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M, Rat
Specificity: This NUR77 (NR4A1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-358 amino acids from human NUR77 (NR4A1) .
Cellular Localisation: Nucleus. Cytoplasm. Mitochondrion. Note=Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27 (PubMed:22427340) Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (PubMed:17761950)
Molecular Weight: 64463
Clone: Polyclonal
Gene Name: NR4A1
Gene ID: 3164
Function: Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity) . May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury (By similarity) .
Summary: Tissue Location: Fetal muscle and adult liver, brain and thyroid.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:500 WB--1:1000
Synonyms: Nuclear receptor subfamily 4 group A member 1, Early response protein NAK1, Nuclear hormone receptor NUR/77, Nur77, Orphan nuclear receptor HMR, Orphan nuclear receptor TR3, ST-59, Testicular receptor 3, NR4A1, GFRP1, HMR, NAK1