Product Description
PAEP Antibody (Center) [APR31277G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This PAEP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 73-101 amino acids from the Central region of human PAEP.
Cellular Localisation: Secreted
Molecular Weight: 20624
Clone: Polyclonal
Gene Name: PAEP
Gene ID: 5047
Function: Glycoprotein that regulates critical steps during fertilization and also has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive tissues that differ in glycosylation and biological activity. Glycodelin-A has contraceptive and immunosuppressive activities (PubMed:9918684, PubMed:7531163) . Glycodelin-C stimulates binding of spermatozoa to the zona pellucida (PubMed:17192260) . Glycodelin-F inhibits spermatozoa-zona pellucida binding and significantly suppresses progesterone-induced acrosome reaction of spermatozoa (PubMed:12672671) . Glycodelin-S in seminal plasma maintains the uncapacitated state of human spermatozoa (PubMed:15883155) .
Summary: Tissue Location: This protein is, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy (PubMed:3667877) Glycodelin-A is expressed in amniotic fluid, endometrium/decidua and maternal serum (at protein level) (PubMed:3194393) . Glycodelin-F is expressed in follicular fluid, luteinized granulosa cells and the oviduct (at protein level) (PubMed:12672671) . Glycodelin-S is expressed in seminal plasma and seminal vesicles (at protein level) (PubMed:9239694) . Glycodelin-C is detected in cumulus cells (at protein level), but cumulus cells do not synthesize Glycodelin-C but take up and convert glycodelin-A and -F vis glycan remodeling (PubMed:17192260) .
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P
Dilution: WB--1:1000 IHC-P--1:100~500
Synonyms: Glycodelin, GD, Placental protein 14, PP14, Pregnancy-associated endometrial alpha-2 globulin, PAEG, PEG, Progestagen-associated endometrial protein, Progesterone-associated endometrial protein, PAEP