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Product Description
PIH1D1 Antibody (Center) [APR31864G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This PIH1D1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 163-192 amino acids from the Central region of human PIH1D1.
Cellular Localisation: Nucleus {ECO:0000250|UniProtKB:Q9CQJ2}.
Molecular Weight: 32363
Clone: Polyclonal
Gene Name: PIH1D1
Gene ID: 55011
Function: Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (PubMed:17636026) . Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre- rRNA transcription (PubMed:22368283, PubMed:24036451) . Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (PubMed:20864032) . Positively regulates the assembly and activity of the mTORC1 complex (PubMed:24036451) .
Summary: Tissue Location: Expressed at low levels in normal mammary epithelial cells (at protein level) (PubMed:24036451) . Highest expression in lung, leukocyte and placenta. Expressed at lower levels in brain, prostate, colon, heart, small intestine, liver, ovary, pancreas, skeletal muscle, spleen, testis and thymus (PubMed:21078300)
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: PIH1 domain-containing protein 1, Nucleolar protein 17 homolog, PIH1D1, NOP17
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