Product Description
PITPNM1 Antibody (N-term) [APR31510G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This PITPNM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 143-171 amino acids from the N-terminal region of human PITPNM1.
Cellular Localisation: Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Lipid droplet. Cleavage furrow. Midbody Note=Peripheral membrane protein associated with Golgi stacks in interphase cells. A minor proportion is associated with the endoplasmic reticulum. Associated with lipid droplets (PubMed:12225667) Dissociates from the Golgi early on in mitosis and localizes to the cleavage furrow and midbody during cytokinesis (PubMed:15125835)
Molecular Weight: 134848
Clone: Polyclonal
Gene Name: PITPNM1
Gene ID: 9600
Function: Catalyzes the transfer of phosphatidylinositol (PI) between membranes (PubMed:22822086, PubMed:10531358) . Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC (PubMed:22822086) . Regulates RHOA activity, and plays a role in cytoskeleton remodeling (PubMed:11909959) . Necessary for normal completion of cytokinesis (PubMed:15125835) . Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus (PubMed:15723057) . Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (PubMed:15545272) . Required for protein export from the endoplasmic reticulum and the Golgi (PubMed:15723057) . Binds calcium ions (PubMed:10022914) .
Summary: Tissue Location: Ubiquitous..
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Membrane-associated phosphatidylinositol transfer protein 1, Drosophila retinal degeneration B homolog, Phosphatidylinositol transfer protein, membrane-associated 1, PITPnm 1, Pyk2 N-terminal domain-interacting receptor 2, NIR-2, PITPNM1, DRES9, NIR2, PITPNM