Product Description
PRDM14 Antibody (N-term) [APR32979G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This PRDM14 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 128-163 amino acids from the N-terminal region of human PRDM14.
Cellular Localisation: Nucleus.
Molecular Weight: 64062
Clone: Polyclonal
Gene Name: PRDM14
Gene ID: 63978
Function: Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity) . Directly up- regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA- 3'.
Summary: Tissue Location: Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level)
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: PR domain zinc finger protein 14, 211-, PR domain-containing protein 14, PRDM14