Product Description
RANGAP1 Antibody (N-term) [APR31158G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This RANGAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 amino acids from the N-terminal region of human RANGAP1.
Cellular Localisation: Cytoplasm. Nucleus, nucleoplasm. Nucleus envelope. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic during interphase Detected at the nuclear envelope during interphase (PubMed:11854305, PubMed:15037602) . Targeted to the nuclear pores after sumoylation (PubMed:11854305) . During mitosis, associates with mitotic spindles, but is essentially not detected at the spindle poles (PubMed:11854305, PubMed:15037602) . Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase (PubMed:11854305) . Mitotic location also requires sumoylation (PubMed:11854305) .
Molecular Weight: 63542
Clone: Polyclonal
Gene Name: RANGAP1
Gene ID: 5905
Function: GTPase activator for RAN (PubMed:8146159, PubMed:8896452, PubMed:16428860) . Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:8896452, PubMed:27160050) . Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050) .
Summary: Tissue Location: Highly expressed in brain, thymus and testis.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P
Dilution: WB--1:1000 IHC-P--1:100~500
Synonyms: Ran GTPase-activating protein 1, RanGAP1, RANGAP1, KIAA1835, SD