Euro
USD
British Pound
NULL
![RASGRP1 Antibody (Center) [APR32209G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/1280x1280/products/872454/1164521/logo__92149.1659788186__42996.1659868664.png?c=2 "RASGRP1 Antibody (Center) [APR32209G]"){kind=logo}
![RASGRP1 Antibody (Center) [APR32209G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/100x100/products/872454/1164521/logo__92149.1659788186__42996.1659868664.png?c=2 "RASGRP1 Antibody (Center) [APR32209G]"){kind=logo}
Product Description
RASGRP1 Antibody (Center) [APR32209G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This RASGRP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 495-521 amino acids from the Central region of human RASGRP1.
Cellular Localisation: Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein Note=Found both in the cytosol and associated with membranes Relocalization to the cell membrane upon activation is F-actin- dependent. Translocates to the Golgi in response to phorbol ester or nerve growth factor. Localizes to somata and dendrites but not to axons of hippocampal pyramidal cells (By similarity) .
Molecular Weight: 90402
Clone: Polyclonal
Gene Name: RASGRP1
Gene ID: 10125
Function: Functions as a calcium- and diacylglycerol (DAG) -regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768, PubMed:27776107, PubMed:29155103) . Activates the Erk/MAP kinase cascade (PubMed:15899849) . Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994, PubMed:27776107, PubMed:29155103) . Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860) . Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types (PubMed:12845332) .
Summary: Tissue Location: Expressed in brain with higher expression in cerebellum, cerebral cortex and amygdala. Expressed in the hematopoietic system. Expressed in T-cells (at protein level) Expressed in NK cells (at protein level) (PubMed:19933860)
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P, FC
Dilution: WB--1:1000
Synonyms: RAS guanyl-releasing protein 1, Calcium and DAG-regulated guanine nucleotide exchange factor II, CalDAG-GEFII, Ras guanyl-releasing protein, RASGRP1, RASGRP
![RASGRP1 Antibody (Center) [APR32209G]](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/872454/1164521/logo__92149.1659788186__42996.1659868664.png?c=2 "RASGRP1 Antibody (Center) [APR32209G]"){kind=logo}
