Product Description
VDAC2 Antibody (N-term) [APR33236G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M, Rat
Specificity: This VDAC2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 51-85 amino acids from the N-terminal region of human VDAC2.
Cellular Localisation: Mitochondrion outer membrane. Membrane. Note=May localize to non-mitochondrial membranes.
Molecular Weight: 31567
Clone: Polyclonal
Gene Name: VDAC2
Gene ID: 7417
Function: Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules (By similarity) . The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV (By similarity) . The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity) . Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterol cholesterol (PubMed:31015432) . Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (PubMed:31015432) .
Summary: Tissue Location: Expressed in erythrocytes (at protein level) (PubMed:27641616) . Expressed in all tissues examined (PubMed:8420959)
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: IHC-P, WB
Dilution: WB--1:2000
Synonyms: Voltage-dependent anion-selective channel protein 2, VDAC-2, hVDAC2, Outer mitochondrial membrane protein porin 2, VDAC2