Product Description
ZDHHC17 Antibody (N-Term) [APR33401G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This ZDHHC17 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 3-37 amino acids from human ZDHHC17.
Cellular Localisation: Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cell junction, synapse, presynaptic cell membrane; Multi-pass membrane protein. Note=Low extracellular Mg (2+) induces increase in Golgi and in post-Golgi membrane vesicles.
Molecular Weight: 72640
Clone: Polyclonal
Gene Name: ZDHHC17 (HGNC:18412)
Gene ID: 23390
Function: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity) . Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HTT (PubMed:15603740, PubMed:15489887, PubMed:19139280, PubMed:28757145) . Also palmitoylates neuronal protein GPM6A as well as SPRED1 and SPRED3 (PubMed:24705354) . Could also play a role in axonogenesis through the regulation of NTRK1 and the downstream ERK1/ERK2 signaling cascade (By similarity) . May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane (PubMed:12393793) . May play a role in Mg (2+) transport (PubMed:18794299) . Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity) .
Summary: Tissue Location: Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney.
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Palmitoyltransferase ZDHHC17, 2.3.1.225, Huntingtin yeast partner H, Huntingtin-interacting protein 14, HIP-14, Huntingtin-interacting protein 3, HIP-3, Huntingtin-interacting protein H, Putative MAPK-activating protein PM11, Putative NF-kappa-B-activating protein 205, Zinc finger DHHC domain-containing protein 17, DHHC-17, ZDHHC17, HIP14, HIP3, HYPH, KIAA0946