Product Description
Fascin Antibody (Center) [APR15935G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This Fascin antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-350 amino acids from the Central region of human Fascin.
Cellular Localisation: Cytoplasm, cytosol. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cell projection, filopodium. Cell projection, invadopodium. Cell projection, microvillus. Cell junction. Note=Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone. Colocalized with DBN1 and F- actin at the transitional domain of the axonal growth cone (By similarity) . {ECO:0000250|UniProtKB:Q61553, ECO:0000269|PubMed:21706053}
Molecular Weight: 54530
Clone: Polyclonal
Gene Name: FSCN1
Gene ID: 6624
Function: Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945) . Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945) . Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786) . Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945) . Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786) .
Summary: Tissue Location: Ubiquitous.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P, FC
Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50
Synonyms: Fascin, 55 kDa actin-bundling protein, Singed-like protein, p55, FSCN1, FAN1, HSN, SNL