Product Description
FATE1 Antibody (Center) [APR04653G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This FATE1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 107-140 amino acids from the Central region of human FATE1.
Cellular Localisation: Mitochondrion. Mitochondrion outer membrane. Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side Note=Localized to specific membrane structures termed mitochondria- associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Also associated with the outer surface of mitochondria at sites that are not in close contact with the ER
Molecular Weight: 20712
Clone: Polyclonal
Gene Name: FATE1
Gene ID: 89885
Function: Involved in the regulation of endoplasmic reticulum (ER) - mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca (2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis (PubMed:27402544) . May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849) .
Summary: Tissue Location: Testis-specific in fetus (aged from 6 to 11 weeks) . In adult, expressed predominantly in testis, with some expression in lung, heart, kidney, adrenal gland and whole brain (PubMed:11694338) Highly expressed in certain types of cancer tissues such as hepatocellular carcinoma, colon and gastric cancer. Weakly expressed in normal pancreas (PubMed:12865919) .
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Fetal and adult testis-expressed transcript protein, Cancer/testis antigen 43, CT43, Tumor antigen BJ-HCC-2, FATE1, FATE