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Product Description
FOXN4 Antibody (Center) [APR04726G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This FOXN4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 314-349 amino acids from the Central region of human FOXN4.
Cellular Localisation: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089}.
Molecular Weight: 55215
Clone: Polyclonal
Gene Name: FOXN4
Gene ID: 121643
Function: Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'- ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development (By similarity) .
Summary: N/A
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Forkhead box protein N4, FOXN4
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