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Product Description
NR2E1 Antibody (Center) [AMM06809G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This NR2E1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-102 amino acids from the Central region of human NR2E1.
Cellular Localisation: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}.
Molecular Weight: 42589
Clone: Polyclonal
Gene Name: NR2E1
Gene ID: 7101
Function: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity) . May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity) . May be involved in retinoic acid receptor (RAR) regulation in retinal cells.
Summary: Tissue Location: Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus.
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Nuclear receptor subfamily 2 group E member 1, Nuclear receptor TLX, Protein tailless homolog, Tll, hTll, NR2E1, TLX
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