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Product Description
RGS1 Antibody (N-term) [AMM08675G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This RGS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-45 amino acids from the N-terminal region of human RGS1.
Cellular Localisation: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol
Molecular Weight: 23858
Clone: Polyclonal
Gene Name: RGS1
Gene ID: 5996
Function: Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors (PubMed:10480894) . Inhibits B cell chemotaxis toward CXCL12 (By similarity) . Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form (PubMed:10480894, PubMed:18434541) .
Summary: Tissue Location: Detected in peripheral blood monocytes (PubMed:10480894) . Expression is relatively low in B-cells and chronic lymphocytic leukemia B-cells; however, in other types of malignant B- cell such as non-Hodgkin lymphoma and hairy cell leukemia, expression is constitutively high (PubMed:8473738) .
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, FC
Dilution: WB--1:1000 FC--1:10~50
Synonyms: Regulator of G-protein signaling 1, RGS1, B-cell activation protein BL34, Early response protein 1R20, RGS1, 1R20, BL34, IER1
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