Product Description
SYCP3 Antibody (N-term) [APR04687G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This SYCP3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 13-46amino acids from the N-terminal region of human SYCP3.
Cellular Localisation: Nucleus {ECO:0000250|UniProtKB:Q60547}. Chromosome {ECO:0000250|UniProtKB:Q60547}. Chromosome, centromere {ECO:0000250|UniProtKB:Q60547}. Note=It is present in early unpaired cores, in the lateral domains of the synaptonemal complex and in the chromosome cores when they separate at diplotene. It is found axial to the metaphase I chromosomes and in association with pairs of sister centromeres. The centromere-associated protein becomes dissociated from the centromeres at anaphase II and is not found in mitotic metaphase centromeres. {ECO:0000250|UniProtKB:Q60547}
Molecular Weight: 27729
Clone: Polyclonal
Gene Name: SYCP3
Gene ID: 50511
Function: Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for centromere pairing during meiosis in male germ cells (By similarity) . Required for normal meiosis during spermatogenesis and male fertility (PubMed:14643120) . Plays a lesser role in female fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2 (By similarity) .
Summary: Tissue Location: Testis-specific.
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Synaptonemal complex protein 3, SCP-3, SYCP3, SCP3