Product Description
XRCC1 Antibody (Center) [APR10935G] | Leading Biology
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This XRCC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-435 amino acids from the Central region of human XRCC1.
Cellular Localisation: Nucleus. Note=Moves from the nucleoli to the global nuclear chromatin upon DNA damage
Molecular Weight: 69477
Clone: Polyclonal
Gene Name: XRCC1
Gene ID: 7515
Function: Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP- ribosyltransferase PARP1 activity.
Summary: Tissue Location: Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level)
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P, FC, IF
Dilution: IF--1:25 WB--1:1000 IHC-P--1:100~500 FC--1:10~50
Synonyms: DNA repair protein XRCC1, X-ray repair cross-complementing protein 1, XRCC1