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Product Description
IRAK Detection Set | PSI-1802 | ProSci
Host: N/A
Reactivity: Human
Homology: N/A
Immunogen: Rabbit polyclonal antibodies were raised against peptides corresponding to amino acid sequences from each of the corresponding proteins.
Tested Application: WB, IHC, IF
Application: N/A
Specificity: N/A
Purification: Antibodies are supplied as affinity chromatography purified IgG.
Clonality: Polyclonal
Isotype: N/A
Conjugate: N/A
Physical State: Liquid
Buffer: PBS containing 0.02% sodium azide.
Concentration: Antibody 1 mg/mL
Peptide 200 μg/mL
Storage Condition: Stable at 4˚C for three months, store at -20˚C for up to one year.
Background: Members of the IRAK (IL-1R-associated kinase)/Pelle family play a major role in IL-1R/TLR mediated inflammatory responses and in innate immunity. IRAK and IRAK-2 regulate the activity of a signaling cascade that mediates the activation of NF-κB and MAP kinase. IRAK-4 interacts with and phosphorylates IRAK, while IRAK-M is thought to inhibit the recruitment and activation of IRAK-4 and IRAK. The importance of the IRAK family in inflammation and immunity is illustrated by the fact that animals lacking IRAK-4 are impaired in their responses to viral and bacterial challenges and are completely resistant to LPS challenge.
For images please see PDF data sheet
User Note: Optimal dilutions for each application to be determined by the researcher.
