Product Description
DMAP1 Antibody | 18-605 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-305 of human DMAP1 (NP_061973.1) .
Research Area: Other
Tested Application: WB, IHC
Application: WB: 1:1000 - 1:4000
IHC: 1:50 - 1:200
Specificiy: N/A
Positive Control 1: SH-SY5Y
Positive Control 2: SW480
Positive Control 3: A375
Positive Control 4: HeLa
Positive Control 5: Jurkat
Positive Control 6: NIH/3T3
Molecular Weight: Observed: 60kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: DMAP1, EAF2, SWC4, MEAF2, DNMAP1, DNMTAP1
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.