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Product Description
Gemtuzumab Ozogamicin (CD33) Antibody, Monoclonal | 10-788 | ProSci
Host: N/A
Reactivity: N/A
Homology: N/A
Immunogen: Humanized / CD33 [Homo sapiens]
Research Area: Drug Analogues
Tested Application: N/A
Application: N/A
Specificiy: N/A
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: >95%
Clonality: Monoclonal
Clone: N/A
Isotype: IgG4-kappa
Conjugate: Unconjugated
Physical State: N/A
Buffer: PBS buffer pH7.5
Concentration: N/A
Storage Condition: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 ˚C for 1-2 weeks. Store at -20 ˚C for 12 months. Store at -80 ˚C for long term storage.
Alternate Name: CDP-771, CMA-676, WAY-CMA-676
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: Gemtuzumab ozogamicin is a recombinant humanized IgG4 kappa antibody which is conjugated with calicheamicin derivative, a cytotoxic antitumor antibiotic isolated from fermentation of Micromonospora echinospora ssp. calichensis. Gemtuzumab ozogamicin has approximately 50% of the antibody loaded with 4-6 moles calicheamicin per mole of antibody Label. The antibody is specifically directed against the CD33 antigen present on leukemic myeloblasts in most patients with acute myeloid leukemia (AML) . By binding to the CD33 antigen on tumors, the cytotoxic agent blocks the growth of cancerous cells and causes cell death.
![CD33 Antibody [hP67.6 (Gemtuzumab) ], Human IgG4](https://cdn11.bigcommerce.com/s-452hpg8iuh/images/stencil/500x659/products/823511/1115095/porsci_lo__79508.1648973713__16731.1649084691__20868.1649235586__20251.1649248189__40712.1657533679.png?c=2 "CD33 Antibody [hP67.6 (Gemtuzumab) ], Human IgG4")