Product Description
c Cbl (Ab 700) Antibody | 79-436 | ProSci
Host: Rabbit
Reactivity: Human
Homology: N/A
Immunogen: c-Cbl (Ab-700) antibody was raised against a peptide sequence around aa. 698~702 (T-E-Y-M-T) derived from Human c-Cbl.
Research Area: Apoptosis, Cancer
Tested Application: WB, IHC
Application: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Specificiy: This antibody detects endogenous level of total c-Cbl protein.
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: 120 kDa
Validation: N/A
Isoform: N/A
Purification: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality: Polyclonal
Clone: N/A
Isotype: N/A
Conjugate: Unconjugated
Physical State: Liquid
Buffer: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+) , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration: 1 mg/mL
Storage Condition: Store antibody at -20˚C for up to one year.
Alternate Name: CBL2, NSLL, C-CBL, RNF55, FRA11B, CSDD2, Signal transduction protein CBL, Proto-oncogene c-CBL, Casitas B-lineage lymphoma proto-oncogene, RING finger protein 55,
User Note: N/A
BACKGROUND: Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.