Product Description
LRP1 Antibody [F1H9] | 13-871 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: Recombinant protein of human LRP1
Research Area: Apoptosis, Cell Cycle, Immunology, Neuroscience, Signal Transduction
Tested Application: WB, IHC, IF, IP
Application: WB: 1:10000 - 1:20000
IHC: 1:50 - 1:100
IF: 1:50 - 1:100
IP: 1:20 - 1:50
Specificiy: N/A
Positive Control 1: HepG2
Positive Control 2: Mouse lung
Positive Control 3: Mouse brain
Positive Control 4: Mouse liver
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Observed: 78kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Monoclonal
Clone: [F1H9]
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: LRP1, APR, LRP, A2MR, CD91, APOER, LRP1A, TGFBR5, IGFBP3R
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712) . This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients.