Product Description
NFKBIZ Antibody | 13-686 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human NFKBIZ (NP_113607.1) .
Research Area: Apoptosis, Cell Cycle, Immunology, Innate Immunity, Transcription
Tested Application: WB, IF
Application: WB: 1:500 - 1:2000
IF: 1:50 - 1:200
Specificiy: N/A
Positive Control 1: LO2
Positive Control 2: THP-1
Positive Control 3: Mouse kidney
Positive Control 4: Rat kidney
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Observed: 68-90kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: IKBZ, INAP, MAIL, NF-kappa-B inhibitor zeta, I-kappa-B-zeta, IL-1 inducible nuclear ankyrin-repeat protein, Ikappa B-zeta variant 3, IkappaB-zeta, ikB-zeta, ikappaBzeta, molecule possessing ankyrin repeats induced by lipopolysaccharide, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS) . The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.