Product Description
Uhrf2 Antibody | 18-614 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 76-359 of mouse Uhrf2 (NP_659122.2) .
Research Area: Apoptosis, Cell Cycle
Tested Application: WB
Application: WB: 1:500 - 1:2000
Specificiy: N/A
Positive Control 1: Jurkat
Positive Control 2: U-87MG
Positive Control 3: HeLa
Positive Control 4: Mouse liver
Positive Control 5: Rat thymus
Positive Control 6: N/A
Molecular Weight: Observed: 110kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: 2310065A22Rik, AI42627AW214556, D130071B19Rik, Nirf, E3 ubiquitin-protein ligase UHRF2, Np95-like ring finger protein, RING-type E3 ubiquitin transferase UHRF2, nuclear protein 97, nuclear zinc finger protein Np97, ubiquitin-like PHD and RING finger domain-containing protein 2, ubiquitin-like-containing PHD and RING finger domains protein 2
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein) , and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.