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Product Description
CDH11 Antibody | 23-407 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 637-796 of human CDH11 (NP_001788.2) .
Research Area: Cancer, Cell Cycle, Signal Transduction
Tested Application: WB, IHC
Application: WB: 1:500 - 1:2000
IHC: 1:50 - 1:100
Specificiy: N/A
Positive Control 1: U-87MG
Positive Control 2: A-549
Positive Control 3: HT-29
Positive Control 4: SKOV3
Positive Control 5: Mouse lung
Positive Control 6: Mouse spleen
Molecular Weight: Observed: 120kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: CDH11, osteoblast cadherin, OSF-4, OB-cadherin, OB, CDHOB, cadherin-11, cadherin 11, type 2, OB-cadherin (osteoblast) , CAD11
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. Expression of this particular cadherin in osteoblastic cell lines, and its upregulation during differentiation, suggests a specific function in bone development and maintenance.
