Product Description
MMP12 Antibody [H7E5] | 13-885 | ProSci
Host: Rabbit
Reactivity: Human
Homology: N/A
Immunogen: Recombinant protein of human MMP12
Research Area: Cancer, Cell Cycle, Signal Transduction
Tested Application: WB, IHC
Application: WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
Specificiy: N/A
Positive Control 1: A-549
Positive Control 2: HeLa
Positive Control 3: MCF7
Positive Control 4: THP-1
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Observed: 37kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Monoclonal
Clone: [H7E5]
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: MMP12, MME, MGC138506, matrix metalloproteinase 12 (macrophage elastase) , matrix metalloproteinase 12, matrix metallopeptidase 12 (macrophage elastase) , macrophage metalloelastase, macrophage elastase, HME
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs) . Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD) . This gene is part of a cluster of MMP genes on chromosome 11.