Product Description
PLS3 Antibody | 19-108 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PLS3 (NP_005023.2) .
Research Area: Cell Cycle, Signal Transduction
Tested Application: WB, IHC, IP
Application: WB: 1:200 - 1:2000
IHC: 1:50 - 1:100
IP: 1:50 - 1:100
Specificiy: N/A
Positive Control 1: HeLa
Positive Control 2: MCF-7
Positive Control 3: BT-474
Positive Control 4: A-431
Positive Control 5: HepG2
Positive Control 6: N/A
Molecular Weight: Observed: 71kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: BMND18, T-plastin, plastin-3, T fimbrin, T plastin
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.) . The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.