Product Description
XRCC3 Antibody | XW-7922 | ProSci
Host: Chicken
Reactivity: Human
Homology: N/A
Immunogen: 213-346
Research Area: Signal Transduction
Tested Application: E, WB
Application: XRCC3 antibody can be used for the detection of DNA-repair protein XRCC3 by ELISA and Western Blot, may also work for ICC and IHC.
Specificiy: N/A
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: 37.9 kDa (calculated)
Validation: N/A
Isoform: N/A
Purification: Immunoaffinity Purified
Clonality: Polyclonal
Clone: N/A
Isotype: N/A
Conjugate: Unconjugated
Physical State: Liquid
Buffer: Phosphate-Buffered Saline. No preservatives added.
Concentration: 1 mg/mL
Storage Condition: XRCC3 antibody can be stored at 4˚C for short term (weeks) . Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Alternate Name: DNA repair protein XRCC3, X-ray repair cross-complementing protein 3, CMM6
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: This protein is a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This protein functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.
DISEASE: Met-241 is associated with the development of cutaneous malignant melanoma.
SUBUNIT: Interacts with RAD51C and RAD51. Part of a complex consisting of RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3.
SIMILARITY: Belongs to the recA family. RAD51 subfamily.