Product Description
ALK Antibody | 13-278 | ProSci
Host: Rabbit
Reactivity: Human, Mouse
Homology: N/A
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 19-300 of human ALK (NP_004295.2) .
Research Area: Cancer, Cell Cycle, Growth Factors, Immunology, Neuroscience, Signal Transduction
Tested Application: WB, IHC
Application: WB: 1:500 - 1:1000
IHC: 1:50 - 1:100
Specificiy: N/A
Positive Control 1: A-431
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Observed: 185kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, pH7.3.
Concentration: N/A
Storage Condition: Store at 4˚C. Avoid freeze / thaw cycles.
Alternate Name: CD246, NBLST3
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2) /EML4 (chromosome 2) , ALK/RANBP2 (chromosome 2) , ALK/ATIC (chromosome 2) , ALK/TFG (chromosome 3) , ALK/NPM1 (chromosome 5) , ALK/SQSTM1 (chromosome 5) , ALK/KIF5B (chromosome 10) , ALK/CLTC (chromosome 17) , ALK/TPM4 (chromosome 19) , and ALK/MSN (chromosome X) .