Product Description
FGFR1 Antibody | 15-021 | ProSci
Host: Rabbit
Reactivity: Human
Homology: N/A
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 22-290 of human FGFR1 (NP_075598.2) .
Research Area: Cancer, Cell Cycle, Growth Factors, Immunology, Neuroscience, Signal Transduction
Tested Application: IHC, IF
Application: IHC: 1:50 - 1:200
IF: 1:50 - 1:200
Specificiy: N/A
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: FGFR1, soluble FGFR1 variant 2, soluble FGFR1 variant 1, proto-oncogene c-Fgr, OTTHUMP00000190880, OTTHUMP00000190876, OTTHUMP00000190875, OGD, N-SAM, KAL2, hydroxyaryl-protein kinase, heparin-binding growth factor receptor, HBGFR, fms-related tyrosine kinase 2, FMS-like tyrosine kinase 2, FLT-2, FLT2, FLJ99988, FLG, fibroblast growth factor receptor 1, FGFR-1, FGFBR, CEK, CD331, bFGF-R-1, BFGFR, basic fibroblast growth factor receptor 1
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.