Product Description
THRB Antibody | 16-254 | ProSci
Host: Rabbit
Reactivity: Human, Mouse, Rat
Homology: N/A
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human THRB (NP_000452.2) .
Research Area: Cell Cycle, Growth Factors, Neuroscience, Signal Transduction, Transcription
Tested Application: WB
Application: WB: 1:500 - 1:2000
Specificiy: N/A
Positive Control 1: HepG2
Positive Control 2: U-87MG
Positive Control 3: Mouse liver
Positive Control 4: Mouse eye
Positive Control 5: Rat liver
Positive Control 6: Rat eye
Molecular Weight: Observed: 53kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: THRB, GRTH, PRTH, THR1, ERBA2, NR1A2, THRB1, THRB2, C-ERBA-2, C-ERBA-BETA
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR) , a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4) , with normal or slightly elevated thyroid stimulating hormone (TSH) . Several alternatively spliced transcript variants encoding the same protein have been observed for this gene.