Product Description
GBP6 Antibody | 6707 | ProSci
Host: Rabbit
Reactivity: Human, Mouse
Homology: N/A
Immunogen: GBP6 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human GBP6.
The immunogen is located within the last 50 amino acids of GBP6.
Research Area: Innate Immunity
Tested Application: E, WB, ICC, IF
Application: GBP6 antibody can be used for detection of GBP6 by Western blot at 0.5 μg/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μg/mL. For immunofluorescence start at 5 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificiy: GBP6 antibody is predicted to not cross-react with other GBP family members.
Positive Control 1: Cat. No. 1201 - HeLa Cell Lysate
Positive Control 2: Cat. No. 17-001 - HeLa Cell Slide
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: GBP6 Antibody is affinity chromatography purified via peptide column.
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: GBP6 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Condition: GBP6 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Alternate Name: GBP6 Antibody: Guanylate-binding protein 6, GTP-binding protein 6, GBP-6
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: GBP6 Antibody: The guanylate-binding proteins (GBPs) , a family of interferon-induced GTP-binding proteins function in innate immunity against microbial and viral pathogens. In humans, there are seven GBPs from hGBP1 to hGBP7. Human GBP1 and GBP2 have been shown to exhibit antiviral activity as well as being able to regulate the inhibition of proliferation and invasion of endothelial cells in response to interferon (IFN) (1, 3) . GBP6 is induced by IFN and hydrolyzes GTP to both GDP and GMP. The precise function of GBP6 is still under investigation.