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Product Description
ULK2 Antibody | 7337 | ProSci
Host: Rabbit
Reactivity: Human
Homology: Predicted species reactivity based on immunogen sequence: Mouse: (82%)
Immunogen: ULK2 antibody was raised against a 17 amino acid peptide near the center of human ULK2 .
The immunogen is located within amino acids 480 - 530 of ULK2.
Research Area: Autophagy
Tested Application: E, WB, IHC-P, IF
Application: ULK2 Antibody can be used for detection of ULK2 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificiy: At least two isoforms of ULK2 are known to exist; this antibody will detect both isoforms. ULK2 antibody is predicted to not cross-react with ULK1.
Positive Control 1: Cat. No. 1303 - Human Brain Tissue Lysate
Positive Control 2: Cat. No. 10-301 - Human Brain Tissue Slide
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: Predicted: 105, 114 kDa
Observed: 100 kDa
Validation: N/A
Isoform: N/A
Purification: ULK2 Antibody is affinity chromatography purified via peptide column.
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: ULK2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration: 1 mg/mL
Storage Condition: ULK2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.
Alternate Name: ULK2 Antibody: ATG1B, Unc51.2, KIAA0623, Unc-51-like kinase 2
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: ULK2 Antibody: ULK2, also known as ATG1B, is a key serine/threonine protein kinase probably acting at the most upstream step of autophagosome formation. Knockout of ULK2 results in a severe defect in the autophagy pathway. ULK2 is highly conserved among eukaryotes and shows high homology with its related protein ULK1. Both ULK1 and ULK2 form a complex with ATG13 and FIP200 that mediates TOR signaling and is essential for autophagy. Like ULK1, ULK2 is also thought to be involved in early neuronal growth and differentiation.
