Product Description
CLEC1 Antibody | 33-024 | ProSci
Host: Rabbit
Reactivity: Human
Homology: N/A
Immunogen: A recombinant protein fragment from the N-terminal portin of human CLEC1 was used as the immunogen for this antibody.
Research Area: Immunology, Signal Transduction
Tested Application: WB
Application: Western blot: 2-5 ug/ml
Provided assay concentrations are suggestions only, CLEC1 antibody titration may be required for optimal results.
Specificiy: N/A
Positive Control 1: N/A
Positive Control 2: N/A
Positive Control 3: N/A
Positive Control 4: N/A
Positive Control 5: N/A
Positive Control 6: N/A
Molecular Weight: N/A
Validation: N/A
Isoform: N/A
Purification: Protein A purified antibody
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Concentration: 0.5 mg/mL
Storage Condition: Aliquot and Store at -20˚C. Avoid freez-thaw cycles.
Alternate Name: N/A
User Note: Optimal dilutions for each application to be determined by the researcher
BACKGROUND: CLEC1 is a C-type lectin receptor and part of the ‘Dectin-1 cluster’ subfamily which also includes Dectin-1, LOX-1, CLEC-2, MICL, CLEC12B, and CLEC9A. Similar to other family members, CLEC1 displays N-liked glycosylation and dimerization characteristics, and is found on dendritic cells, monocytes and granulocytes. However, unlike other family members, CLEC1 expression level is upregulated by IL-10 and TGFb, but not by pro-inflammatory stimuli, and it is expressed on endothelial cells. Enhanced expression at allograft sites suggests CLEC1 may have an immune-regulatory function and may support allograft tolerance.