Product Description
LCP1 Antibody | 19-733 | ProSci
Host: Rabbit
Reactivity: Human, Mouse
Homology: N/A
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human LCP1 (NP_002289.2) .
Research Area: Cancer, Cell Cycle, Immunology, Signal Transduction
Tested Application: WB, IP
Application: WB: 1:500 - 1:2000
IP: 1:20 - 1:50
Specificiy: N/A
Positive Control 1: Raji
Positive Control 2: K-562
Positive Control 3: DU145
Positive Control 4: Jurkat
Positive Control 5: Mouse thymus
Positive Control 6: Mouse spleen
Molecular Weight: Observed: 70kDa
Validation: N/A
Isoform: N/A
Purification: Affinity purification
Clonality: Polyclonal
Clone: N/A
Isotype: IgG
Conjugate: Unconjugated
Physical State: Liquid
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration: N/A
Storage Condition: Store at -20˚C. Avoid freeze / thaw cycles.
Alternate Name: LCP1, CP64, DKFZp781A23186, FLJ25423, FLJ26114, FLJ39956, L-PLASTIN, LC64P, PLS2, LPL, HEL-S-37
User Note: Optimal dilutions for each application to be determined by the researcher.
BACKGROUND: Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.) . However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.